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Last Updated: December 22, 2024

Claims for Patent: 11,213,519

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Summary for Patent: 11,213,519

Title:	Compositions and methods for treating diseases of the nail
Abstract:	Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.
Inventor(s):	Winckle; Gareth (Biot, FR), Fieldson; Gregory T. (Morgantown, WV)
Assignee:	BAUSCH HEALTH IRELAND LIMITED (Dublin, IE)
Application Number:	16/722,715
Patent Claims:	1. A method for the treatment of onychomycosis comprising topically applying to the surface of the nail of an individual suffering from onychomycosis a pharmaceutical composition comprising ethanol, diisopropyl adipate, C12-15 alkyl lactate, cyclomethicone, and a triazole antifungal agent, wherein the composition is formulated as a solution, and wherein the application of the composition is in an amount and for a time sufficient to ameliorate the symptoms of the onychomycosis. 2. The method of claim 1 wherein the triazole antifungal agent is (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol. 3. The method of claim 1 wherein the composition does not comprise a polymeric film forming compound. 4. The method of claim 1, wherein the ethanol is present in the composition at a concentration of at least 50% w/w; wherein the cyclomethicone is present in the composition at a concentration less than 25% w/w; and wherein the diisopropyl adipate and C12-15 alkyl lactate are present in the composition at a total concentration between 15 and 50% w/w. 5. The method of claim 4 wherein the triazole antifungal agent is (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol. 6. The method of claim 4 wherein the composition does not comprise a polymeric film forming compound.

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