Claims for Patent: 11,234,985

Summary for Patent: 11,234,985

Title:	Antiviral therapy
Abstract:	The present invention relates to combinations of compounds comprising HIV integrase inhibitors and other therapeutic agents. Such combinations are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
Inventor(s):	Underwood; Mark Richard (Research Triangle Park, NC)
Assignee:	Viiv Healthcare Company (N/A)
Application Number:	16/835,733
Patent Claims:	1. A combination consisting essentially of a compound of formula (I) ##STR00005## or a pharmaceutically acceptable salt thereof, and lamivudine, or a pharmaceutically acceptable salt thereof. 2. A combination according to claim 1 wherein the pharmaceutically acceptable salt of the compound of formula (I) is a sodium salt. 3. A method of treatment of HIV infection consisting essentially of administering to a human in need thereof, a compound of formula (I) ##STR00006## or a pharmaceutically acceptable salt thereof, and lamivudine, or a pharmaceutically acceptable salt thereof. 4. The method according to claim 3, wherein the pharmaceutically acceptable salt of a compound of formula (I) is the sodium salt. 5. A pharmaceutical composition consisting essentially of a compound of formula (I) ##STR00007## or a pharmaceutically acceptable salt thereof, and lamivudine, or a pharmaceutically acceptable salt thereof. 6. The composition according to claim 5, wherein the pharmaceutically acceptable salt of a compound of formula (I) is a sodium salt. 7. The combination according to claim 1 wherein the combination is administered simultaneously. 8. The combination according to claim 1 wherein the combination is administered sequentially. 9. A method of treatment according to claim 3 wherein the compound of formula (I) or a pharmaceutically acceptable salt thereof, and lamivudine or a pharmaceutically acceptable salt thereof, are administered simultaneously. 10. A method of treatment according to claim 3 wherein the compound of formula (I) or a pharmaceutically acceptable salt thereof, and lamivudine or a pharmaceutically acceptable salt thereof, are administered sequentially. 11. A patient pack consisting essentially of the compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof, and lamivudine or a pharmaceutically acceptable salt thereof. 12. A combination consisting essentially of a sodium salt of a compound of formula (I) ##STR00008## and lamivudine. 13. A method of treatment of an HIV infection consisting essentially of administering to a human in need thereof, a sodium salt of a compound of formula (I) ##STR00009## and lamivudine. 14. A method of treatment according to claim 13 wherein the sodium salt of the compound of formula (I) and lamivudine are administered simultaneously. 15. A method of treatment according to claim 13 wherein the sodium salt of the compound of formula (I) and lamivudine are administered sequentially. 16. A pharmaceutical composition consisting essentially of a sodium salt of a compound of formula (I) ##STR00010## and lamivudine.