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Last Updated: December 23, 2024

Claims for Patent: 11,382,957

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Summary for Patent: 11,382,957

Title:	Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid
Abstract:	The present invention relates to solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and their use in medicine.
Inventor(s):	Sauerberg; Per (Farum, DK), Bjerregaard; Simon (Hilleroed, DK), Nielsen; Flemming Seier (Frederikssund, DK)
Assignee:	Novo Nordisk A/S (Bagsvaerd, DK)
Application Number:	17/180,370
Patent Claims:	1. A solid composition for oral administration comprising a GLP-1 agonist, a salt of N-(8-(2-hydroxybenzyol)amino)caprylic acid, and at least one excipient selected from the group consisting of a lubricant, binder, and filler; wherein the GLP-1 agonist is semaglutide; and wherein the composition comprises at least 60% (w/w) of the salt of N-(8-(2-hydroxybenzyol)amino)caprylic acid. 2. The composition according to claim 1, wherein the composition is in the form of a tablet. 3. The composition according to claim 1, wherein the salt of N-(8-(2-hydroxybenzyol)amino)caprylic acid is sodium N-(8-(2-hydroxybenzyol)amino)caprylate (SNAC). 4. The composition according to claim 1, wherein the amount of the salt of N-(8-(2-hydroxybenzyol)amino)caprylic acid is in the range of 0.6-2.1 mmol. 5. The composition according to claim 1, wherein the amount of the semaglutide is in the range of 0.01 mg to 100 mg. 6. The composition according to claim 1, wherein the amount of the semaglutide is in the range of 0.01 to 25 .mu.mol. 7. The composition according to claim 1, wherein the lubricant is magnesium stearate. 8. The composition according to claim 1, wherein the binder is povidone. 9. The composition according to claim 1, wherein the filler is microcrystalline cellulose.

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