Claims for Patent: 11,395,856

Summary for Patent: 11,395,856

Title:	Lipid-encapsulated gas microsphere compositions and related methods
Abstract:	The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
Inventor(s):	Robinson; Simon P. (Stow, MA), Siegler; Robert W. (Chelmsford, MA), Onthank; David C. (Groton, MA), Nguyen; Nhung Tuyet (Westford, MA)
Assignee:	Lantheus Medical Imaging, Inc. (North Billerica, MA)
Application Number:	16/779,872
Patent Claims:	1. A composition comprising a non-aqueous mixture comprising one or more phospholipids selected from DPPA, DPPC and PEG5000-DPPE, in propylene glycol and/or glycerol, and a perfluorocarbon gas, wherein the non-aqueous mixture comprises equal to or less than 5% w/w (weight/weight) of water. 2. The composition of claim 1, wherein the non-aqueous mixture comprises less than 5% w/w (weight/weight) of water. 3. The composition of claim 1, wherein the composition further comprises a buffer. 4. The composition of claim 1, wherein the composition further comprises a non-phosphate buffer. 5. The composition of claim 1, wherein the one or more phospholipids are present in a concentration of about 0.9 to about 7.5 mg per ml of non-aqueous mixture. 6. The composition of claim 1, wherein the one or more phospholipids are present in a concentration of about 3.75 mg per ml of non-aqueous mixture. 7. The composition of claim 1, wherein the composition comprises less than 5% impurities when stored at room temperature for about 3 months. 8. The composition of claim 1, wherein the perfluorocarbon gas is perfluoropropane gas. 9. The composition of claim 1, wherein PEG5000-DPPE is MPEG5000-DPPE. 10. A method of forming an ultrasound contrast agent formulation comprising adding glycerol and/or propylene glycol and/or an aqueous diluent to the composition of claim 1 to form an ultrasound contrast agent formulation. 11. The method of claim 10, further comprising then activating the ultrasound contrast agent formulation to form lipid-encapsulated perfluorocarbon gas microspheres. 12. A method of using lipid-encapsulated perfluorocarbon gas microspheres comprising (1) forming lipid-encapsulated perfluorocarbon gas microspheres by (a) adding an aqueous diluent to the composition of claim 1 to form a mixture, and (b) activating the mixture to form lipid-encapsulated perfluorocarbon gas microspheres, and (2) administering the lipid-encapsulated perfluorocarbon gas microspheres to a subject.