Claims for Patent: 11,439,610

Summary for Patent: 11,439,610

Title:	Compositions and methods for enhancing the efficacy of contraceptive microbicides
Abstract:	The present disclosure relates to compositions and methods for contraception that also enhance the efficacy of microbicides. Such compositions serve the dual purpose of preventing pregnancy and lessening the risk of spreading sexually transmitted diseases. More specifically, the compositions and methods relate to synergistic contraceptive microbicide and antiviral compositions comprising a combination of a contraceptive microbicide and an antiviral agent in an acidic carrier that enhances the efficacy of both the contraceptive microbicide and antiviral agent.
Inventor(s):	Guthrie; Wendell (San Diego, CA)
Assignee:	Evofem, Inc. (San Diego, CA)
Application Number:	16/738,868
Patent Claims:	1. A composition comprising: a) 3-5% alginic acid; b) 2.5-3.5% xanthan gum; c) 1-7% L-lactic acid; and d) an aqueous-based pharmaceutically acceptable carrier, wherein the composition is essentially free of D-lactic acid. 2. The composition of claim 1, further comprising a humectant. 3. The composition of claim 2, wherein the humectant is selected from the group consisting of glycerol, polyethylene glycol, polypropylene glycol, sorbitol, and triacetin. 4. The composition of claim 3, further comprising a preservative. 5. The composition of claim 4, wherein the preservative is selected from the group consisting of benzoic acid, sodium benzoate, methylparaben, ethylparaben, butylparaben, propylparaben, benzyalkonium chloride, phenylmercuric nitrate, and chlorhexidine. 6. The composition of claim 1, wherein the alginic acid has an average molecular weight in the range of 20,000 to 300,000 g/mole. 7. The composition of claim 1 comprising 3.5-4.5% alginic acid, 2.5-3.5% xanthan gum, and 1-4% L-lactic acid. 8. The composition of claim 1, wherein the pH of the composition is 5.0 or below. 9. The composition of claim 1, wherein the composition maintains the pH of the vagina at pH 5.0 or below in the presence of normal amounts of ejaculate. 10. A composition consisting essentially of: a) 3-5% alginic acid; b) 2.5-3.5% xanthan gum; c) 1-7% L-lactic acid; d) potassium bitartrate; e) glycerin; f) benzoic acid; g) citric acid; and h) water, wherein the composition is essentially free of D-lactic acid. 11. The composition of claim 10, wherein the alginic acid has an average molecular weight in the range of 20,000 to 300,000 g/mole. 12. The composition of claim 10, wherein the pH of the composition is 5.0 or below. 13. The composition of claim 10 comprising 3.5-4.5% alginic acid, 2.5-3.5% xanthan gum, and 1-4% L-lactic acid. 14. The composition of claim 1, further comprising potassium bitartrate, glycerin, benzoic acid, and citric acid, wherein the pH of the composition is 5 or below. 15. The composition of claim 14, further comprising water. 16. The composition of claim 7, further comprising potassium bitartrate, glycerin, benzoic acid, and citric acid, wherein the pH of the composition is 5 or below. 17. The composition of claim 16, further comprising water.