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Last Updated: March 14, 2025

Claims for Patent: 11,459,305

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Summary for Patent: 11,459,305

Title:	Processes for the preparation of uracil derivatives
Abstract:	The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
Inventor(s):	Gallagher Donald J., Treiber Laszlo R., Hughes Robert Michael, Campopiano Onorato, Wang Peng, Zhao Yuxin, Chou Shine K., Ouellette Michael Allen, Hettinger Donald Nicholas
Assignee:	Neurocrine Biosciences, Inc.
Application Number:	US16739263
Patent Claims:	2. The formulation of claim 1 , wherein the excipient or other carrier is mannitol claim 1 , polyvinyl pyrrolidone and/or hydroxypropylmethylcellulose.3. A method for treating a condition selected from prostate cancer claim 1 , breast cancer claim 1 , endometriosis claim 1 , uterine leiomyoma (fibroids) claim 1 , ovarian cancer claim 1 , prostatic hyperplasia claim 1 , assisted reproductive therapy claim 1 , and precocious puberty in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of the formulation of .4. The method of claim 3 , wherein the condition is endometriosis.5. The method of claim 3 , wherein the condition is uterine leiomyoma (fibroids).7. The formulation of claim 6 , wherein the excipient or other carrier is a polymer.8. The formulation of claim 6 , wherein the excipient or other carrier is selected from mannitol claim 6 , polyvinyl pyrrolidone and hydroxypropylmethylcellulose.9. A method for treating a condition selected from prostate cancer claim 6 , breast cancer claim 6 , endometriosis claim 6 , uterine leiomyoma (fibroids) claim 6 , ovarian cancer claim 6 , prostatic hyperplasia claim 6 , assisted reproductive therapy claim 6 , and precocious puberty in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of the formulation of .10. The method of claim 9 , wherein the condition is endometriosis.11. The method of claim 9 , wherein the condition is uterine leiomyoma (fibroids).

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