Claims for Patent: 11,478,488

Summary for Patent: 11,478,488

Title:	Co-crystals of tramadol and coxibs
Abstract:	The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
Inventor(s):	Plata-Salaman Carlos-Ramón, Tesson Nicolas
Assignee:	ESTEVE PHARMACEUTICALS, S.A.
Application Number:	US16720574
Patent Claims:	2. The method according to claim 1 , characterized in that the pain to be treated is severe to moderate pain.3. The method according to claim 1 , characterized in that the molecular ratio between the (rac)-tramadol⋅HCl and celecoxib is 1:1.4. The method according to claim 1 , characterized in that the molecular ratio between the (rac)-tramadol⋅HCl and celecoxib is 1:1 and that the pain to be treated is severe to moderate pain.5. The method according to claim 1 , comprising administering (rac)-tramadol⋅HCl and celecoxib in a molecular ratio of 1:1 claim 1 , characterized in that it has an orthorhombic unit cell with the following dimensions:{'br': None, 'i': 'a=', '11.0323(7) Å'}{'br': None, 'i': 'b=', '18.1095(12) Å'}{'br': None, 'i': 'c=', '17.3206(12) Å.'}