Claims for Patent: 3,674,870

Summary for Patent: 3,674,870

Title:	PHENYL BENZOIC ACID COMPOUNDS IN COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION
Abstract:	The invention relates to a method of treating inflammation by administering substituted 5-(phenyl) benzoic acids, esters and non-toxic pharmaceutically accepted salts thereof to patients.
Inventor(s):	Ruyle; William V. (Scotch Plains, NJ), Sarett; Lewis H. (Skillman, NJ), Matzuk; Alexander R. (Colonia, NJ)
Assignee:	Merck & Co. Inc. (Rahway, NJ)
Application Number:	05/044,868
Patent Claims:	1. A method of treating inflammation which comprises orally administering to a patient daily doses of from about 1 mg. to 140 mg./kg. body weight per day of a compound of the formula ##SPC5## wherein X is halogen; R.sub.1 is hydroxy; R.sub.2 is hydrogen or lower alkanoyl; R.sub.3 is hydrogen or methyl; or a pharmaceutically non-toxic salt of the acid. 2. A method of claim 1 wherein the compound to be administered is 2-acetoxy-3-methyl-5-(4'-fluorophenyl) benzoic acid. 3. A method of treating inflammation which comprises orally administering to a patient daily doses of from about 2 mg. to 70 mg./kg. body weight per day of a compound of the formula: wherein R.sub.2 is hydrogen or lower alkanoyl or a pharmaceutically non-toxic salt of the acid. 4. A method of claim 3 wherein the compound to be administered is 2-hydroxy-5-(pentafluorophenyl) benzoic acid. 5. A method of claim 3 wherein the compound to be administered is 2-hydroxy-5-(2'-fluorophenyl) benzoic acid. 6. A method of claim 3 wherein the compound to be administered is 2-hydroxy-5-(3'-fluorophenyl) benzoic acid. 7. A method of claim 3 wherein the compound to be administered is 2-hydroxy-5-(2',4'-difluorophenyl) benzoic acid. 8. A method of treating inflammation which comprises orally administering to a patient daily doses of from about 2 mg. to 70 mg./kg. body weight per day of a compound of the formula: wherein R.sub.2 is hydrogen or lower alkanoyl or a pharmaceutically non-toxic salt thereof. 9. A method of claim 8 wherein the compound to be administered is 2-hydroxy-5-(4'-fluorophenyl) benzoic acid. 10. A method of claim 8 wherein the compound to be administered is 2-acetoxy-5-(4'-fluorophenyl) benzoic acid. 11. A method of claim 8 wherein the compound to be administered is the choline salt of 2-hydroxy-5-(4'-fluorophenyl)benzoic acid. 12. A pharmaceutical anti-inflammatory composition consisting of an effective amount of at least one member selected from the group consisting of the compounds of the formula: ##SPC6## wherein X is halogen; R.sub.1 is hydroxy; R.sub.2 is hydrogen or lower alkanoyl; R.sub.3 is hydrogen or methyl; and a pharmaceutically non-toxic salt of the acid as an active ingredient, together with a pharmaceutically acceptable carrier. 13. A composition as in claim 12 wherein the active ingredient is 2-acetoxy-3-methyl-5-(4'-fluorophenyl)benzoic acid. 14. A pharmaceutical antiinflammatory composition consisting of an effective amount of at least one member selected from the group consisting of the compounds of the formula: wherein R.sub.2 is hydrogen or lower alkanoyl and a pharmaceutically non-toxic salt thereof as an active ingredient together with a pharmaceutically acceptable carrier. 15. A composition as in claim 14 wherein the active ingredient is 2-hydroxy-5-(pentafluorophenyl) benzoic acid. 16. A composition as in claim 14 wherein the active ingredient is 2-hydroxy-5-(2'-fluorophenyl) benzoic acid. 17. A composition as in claim 14 wherein the active ingredient is 2-hydroxy-5-(3'-fluorophenyl) benzoic acid. 18. A composition as in claim 14 wherein the active ingredient is 2-hydroxy-5-(2',4'-difluorophenyl) benzoic acid. 19. A pharmaceutical antiinflammatory composition consisting of an effective amount of at least one member selected from the group consisting of the compounds of the formula: wherein R.sub.2 is hydrogen or acetyl or a pharmaceutically non-toxic salt thereof, as an active ingredient, together with a pharmaceutically acceptable carrier. 20. A composition as in claim 19 wherein the active ingredient is 2-hydroxy-5-(4'-fluorophenyl) benzoic acid. 21. A composition as in claim 19 wherein the active ingredient is 2-acetoxy-5-(4'-fluorophenyl) benzoic acid. 22. A composition as in claim 19 wherein the active ingredient is the choline salt of 2-hydroxy-5-(4'-fluorophenyl)benzoic acid.