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Last Updated: November 22, 2024

Claims for Patent: 3,726,919

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Summary for Patent: 3,726,919

Title:	BENZENE DERIVATIVES
Abstract:	Benzene derivatives of the formula: ##SPC1## Wherein R.sup.1 represents alkanoylamino of not more than nine carbon atoms, R.sup.2 represents alkyl of one through six carbon atoms, and R.sup.3 represents alkyl of one through six carbon atoms or cycloalkyl of three through six carbon atoms, possess pharmacodynamic properties and are useful in the treatment of various cardiac disorders. Moreover, they can be used as starting materials for corresponding compounds in which the ketone group --COR.sup.2 is replaced by a grouping ##SPC2## Wherein R.sup.4 represents, for example, a hydroxy group, or an optionally substituted ureido or thioureido group, which possess similar pharmacodynamic properties.
Inventor(s):	Wooldridge; Kenneth Robert Harry (Brentwood, EN), Basil; Berkeley (Highwood, Near Chelmsford, EN)
Assignee:	May & Baker Limited (Dagenham, Essex, EN)
Application Number:	04/785,403
Patent Claims:	1. A compound of the formula: ##SPC8## wherein R.sup.1 represents alkanoylamino of one through nine carbon atoms, R.sup.2 represents alkyl of one through six carbon atoms, and R.sup.3 represents alkyl of one through six carbon atoms or cycloalkyl of three through six carbon atoms, and non-toxic acid addition salts thereof. 2. A compound according to claim 1 wherein R.sup.1 represents alkanoylamino of one through six carbon atoms. 3. A compound according to claim 1 wherein R.sup.3 represents alkyl of one through six carbon atoms. 4. A compound according to claim 1 wherein R.sup.3 represents isopropyl. 5. The compound according to claim 1 which is 5'-acetamido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone, and non-toxic acid addition salts thereof. 6. The compound according to claim 1 which is 2'-(2-hydroxy-3-isopropylaminopropoxy)-5'-propionamidopropiophenone, and non-toxic acid addition salts thereof. 7. The compund according to claim 1 which is 5'-butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone, and non-toxic acid addition salts thereof.

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