Claims for Patent: 3,885,046

Summary for Patent: 3,885,046

Title:	Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
Abstract:	The compounds m-chloro-.alpha.-t-butylaminopropiophenone and m-fluoro-.alpha.-t-butylaminopropiophenone or salts thereof. The compounds are useful in the treatment of mammals suffering from a depressed state.
Inventor(s):	Mehta; Nariman B. (Raleigh, NC)
Assignee:	Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:	05/390,845
Patent Claims:	1. A pharmaceutical composition suitable for use in the treatment of the depressed state comprising an antidepressant-effective amount of a compound of the general formula ##SPC3## wherein X is chlorine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier therefor. 2. A composition as claimed in claim 1 wherein the compound or its acid addition salt thereof is present as 5 to 95% by weight of the composition. 3. A composition as claimed in claim 1 suitable for oral or rectal administration and in the form of a discrete dosage unit containing from 15 to 500 milligram of the compound or a pharmaceutically acceptable acid addition salt thereof calculated as the weight of base present in the composition. 4. A composition as claimed in claim 1 suitable for parenteral administration in the form of a discrete dosage unit containing from 7.5 to 250 milligram of the compound or a pharmaceutically acceptable acid addition salt thereof, calculated as the weight of base in the composition. 5. A tablet suitable for oral administration comprising an antidepressant-effective amount of m-chloro-.alpha.-t-butylaminopropiophenone or m-fluoro-.alpha.-t-butylaminopropiophenone or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier. 6. A capsule suitable for oral administration containing an antidepressant-effective amount of m-chloro-.alpha.-t-butylaminopropiophenone or m-fluoro-.alpha.-t-butylaminopropiophenone or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier. 7. A sterile solution or suspension suitable for parenteral administration comprising an antidepressant-effective amount of m-chloro-.alpha.-t-butylaminopropiophenone or m-fluoro-.alpha.-t-butylaminopropiophenone or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier. 8. A tablet suitable for oral administration comprising 15 to 500 milligram of m-chloro-.alpha.-t-butylaminopropiophenone hydrochloride and a pharmaceutically acceptable carrier. 9. A method of treating a depressed state in mammals which comprises the administration of an effective antidepressive dose to a mammal of a compound of the formula ##SPC4## wherein X is chlorine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier. 10. A method as claimed in claim 9 comprising the oral or rectal administration of a dose of 10 to 100 milligram per killogram body weight or the mammal, said dose calculated as the base. 11. A method as claimed in claim 9 comprising the parenteral administration of a dose of 5 to 50 milligram per killogram body weight of the mammal, said dose calculated as the base. 12. A method as claimed in claim 9 comprising the administration to a human of an effective-antidepressant dose of m-chloro-.alpha.-t-butylaminopropiophenone hydrochloride. 13. A method according to claim 10 wherein the mammel is a human. 14. A method according to claim 11 wherein the mammal is a human.