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Last Updated: April 5, 2025

Claims for Patent: 3,968,249

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Summary for Patent: 3,968,249

Title:	Method of treating malignant neoplastic disease
Abstract:	This invention relates to pharmaceutical preparations and the method of utilizing them in the treatment of malignant neoplastic diseases. The administration of hydroxyurea or 1-ethyl-1-hydroxyurea has been found to be effective for the amelioration of the symptoms of various forms of leukemia, carcinoma or sarcoma in various organs of the body.
Inventor(s):	Bernstein; Jack (New Brunswick, NJ), Stearns; Barbara (Highland Park, NJ)
Assignee:	E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:	04/729,450
Patent Claims:	1. A method of treating malignant neoplastic disease which comprises administering to a host afflicted with such disease a composition comprising about 50 mg. to about 4 gm. of hydroxyurea in pharmaceutical dosage form. 2. A method for the alleviation of malignant neoplastic disease which comprises administering to a human host afflicted with such disease about 20 to 80 mg./kg. per day of hydroxyurea in pharmaceutical dosage form. 3. A method for producing remissions in patients suffering from leukemia, carcinoma or sarcoma which comprises administering to said patient about 50 mg. to 4 gm. of hydroxyurea in one day in a pharmaceutical unit dosage form. 4. A method as in claim 3 for producing remissions in leukemia. 5. A method as in claim 3 for producing remissions in chronic myelocytic leukemia. 6. A method as in claim 4 wherein the amount is 20 to 60 mg./kg. per day. 7. A method as in claim 3 for producing remissions in carcinoma. 8. A method as in claim 7 for producing remissions in carcinoma of the bladder. 9. A method as in claim 7 for producing remissions in carcinoma of the ovary. 10. A method as in claim 3 for producing remissions in melanoma.

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