You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: March 28, 2025

Claims for Patent: 3,980,778

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 3,980,778

Title:	Anti-inflammatory steroid
Abstract:	The disclosure covers the preparation of the compound, 6.alpha.,9.alpha.-difluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna -1,4-diene-3,20-dione 17.alpha.,21-diacetate, (1) and methods and formulations for its anti-inflammatory use topically, orally and parenterally.
Inventor(s):	Ayer; Donald E. (Kalamazoo, MI), Schlagel; Carl A. (Kalamazoo, MI), Flynn; Gordon L. (Ann Arbor, MI)
Assignee:	The Upjohn Company (Kalamazoo, MI)
Application Number:	05/579,177
Patent Claims:	1. The chemical compound 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.,21-trihydroxy-16.beta.-methy lpregna-1,4-diene-3,20-dione. 2. A therapeutic composition for topical or local application for treatment of inflammation of skin or mucous membrane comprising from about 0.001% w/w to about 1.0% w/w of 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.,21-trihydroxy-16.beta.-methy lpregna-1,4-diene-3,20-dione 17,21-diacetate in association with a pharmaceutical carrier. 3. A method for the treatment of inflammation of skin or mucous membrane comprising topical or local application of from about 0.001% w/w to about 1.0% w/w of 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.,21-trihydroxy-16.beta.-methy lpregna-1,4-diene-3,20-dione 17,21-diacetate in association with a pharmaceutical carrier. 4. A therapeutic composition comprising, in unit dosage form, from about 0.1 to 25 mg. of 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.,21-trihydroxy-16.beta.-methy lpregna-1,4-diene-3,20-dione 17,21-diacetate in association with a pharmaceutical carrier. 5. The composition of claim 4 suitable for parenteral administration wherein said pharmaceutical carrier is a sterile vehicle and said compound is present in a concentration of from about 0.01 to about 10% w/v of the composition. 6. A method for treating inflammatory conditions systemically which comprises administering from about 0.1 to about 25 mg. of 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.,21-trihydroxy-16.beta.-methy l-pregna-1,4-diene-3,20-dione 17,21-diacetate in association with a pharmaceutical carrier. 7. The therapeutic composition as claimed in claim 2 comprising, in addition, a topically effective amount of an antibacterial agent. 8. The therapeutic composition as claimed in claim 2 comprising, in addition, a therapeutically effective amount of an antifungal agent. 9. The composition of claim 7 in which the antibacterial agent is neomycin sulfate. 10. The therapeutic composition as claimed in claim 2 comprising, in addition, a topically effective amount of an antibacterial agent and a topically effective amount of an antifungal agent. 11. The composition of claim 8 in which the antifungal agent is chloroxine. 12. The composition of claim 10 in which the antibacterial agent is neomycin sulfate and the antifungal agent is chloroxine.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.