Claims for Patent: 4,062,966
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Summary for Patent: 4,062,966
| Title: | 1-Aryl-2-(1-imidazolyl) alkyl ethers and thioethers |
| Abstract: | Novel 1-aryl-2-(1-imidazolyl)alkyl ethers and thioethers having anti-fungal properties are disclosed. |
| Inventor(s): | Gymer; Geoffrey E. (Sandwich, EN) |
| Assignee: | Pfizer Inc. (New York, NY) |
| Application Number: | 05/676,104 |
| Patent Claims: |
1. A 1-aryl-2-(1-imidazolyl)alkyl ether or thioether having the formula: ##STR12## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1, R.sup.2,
R.sup.3 and R.sup.4 are each hydrogen or alkyl of from 1 to 6 carbon atoms; Ar is phenyl, substituted phenyl, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms, thienyl or halothienyl; Z is oxygen
or sulfur; n is 1 or 2; and Y is thienyl or substituted thienyl group, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms.
2. A compound as claimed in claim 1 in which Ar is phenyl or substituted phenyl. 3. A compound as claimed in claim 1 in which Z is oxygen. 4. A compound as claimed in claim 1 in which Z is sulfur. 5. A compound as claimed in claim 1 in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom. 6. A compound as claimed in claim 2 in which Ar is a 2,4-dichlorophenyl group. 7. A compound as claimed in claim 1 in which n is 1. 8. A compound as claimed in claim 1 in which Y is a thienyl or halothienyl group. 9. 1-[2,4-dichloro-.beta.-(3-thienylmethoxy)phenethyl]imidazole. 10. 1-[2,4-dichloro-.beta.-(5-chloro-2-thienylmethoxy)phenethyl]imidazole. 11. 1-[2,4-dichloro-.beta.-(2-chloro-3-thienylmethoxy)phenethyl]imidazole. 12. 1-[2,4-dichloro-.beta.-(2-thienylmethoxy)phenethyl]imidazole. 13. 1-[2,4-dichloro-.beta.-(2,5-dichloro-3-thienylmethoxy)pheneth yl]imidazole. 14. 1-[2,4-di chloro-.beta.-(5-chloro-2-thienylmethylthio)phenethyl]imidazole. 15. 1-[2,4-dichloro-.beta.-(3-thienylmethylthio)phenethyl]imidazole. 16. 1-[2-(5-chloro-2-thienyl)-2-(3-chloro-2-thienylmethoxy)ethyl] imidazole. 17. A composition in dosage unit form useful for the treatment of fungal infections comprising a pharmaceutical carrier containing from about 10 mg. to about 3,000 mg. of a compound as claimed in claim 1. 18. A method of treating fungal infections in animals which comprises parentally or orally administering to an animal in need of such treatment an antifungal effective amount of a compound as claimed in claim 1. |
