Claims for Patent: 4,085,225

Summary for Patent: 4,085,225

Title:	Oxime ethers having anti-depressive activity
Abstract:	Novel 4'-trifluoromethylvalerophenone 0-(2-aminoethyl)oximes are found to exhibit a strong anti-depressive activity based on a strong serotone potentiation but with the absence of monoamino/oxidase inhibition and undesirable side effects.
Inventor(s):	Welle; Hendricus Bernardus Antonius (Utrecht, NL), Claassen; Volkert (Weesp, NL)
Assignee:	U.S. Philips Corporation (New York, NY)
Application Number:	05/668,461
Patent Claims:	1. Oxime ether compounds of the formula ##STR10## and salts thereof with pharmaceutically acceptable acids, in which formula R is a cyano group, a cyanomethyl group, a methoxymethyl group or an ethoxymethyl group. 2. The 5-Methoxy-4'-trifluoromethylvalerophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 1. 3. The 5-Ethoxy-4'-trifluoromethylvalerophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 1. 4. An oxime compound of the formula: ##STR11## wherein R is cyano or cyanomethyl. 5. The 4-Cyano-4'-trifluoromethylbutyrophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 4. 6. The 5-Cyano-4'-trifluoromethylvalerophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 4. 7. An antidepressive composition comprising a compound of claim 1 in an antidepressively effective amount and a pharmaceutically acceptable carrier therefore. 8. A method of treating patients suffering from depression comprising administering to said patients a composition of claim 7 in an antidepressively effective amount.