Claims for Patent: 4,137,309

Summary for Patent: 4,137,309

Title:	Therapeutic treatment
Abstract:	Organophosphonate compounds are used in the treatment of sickle cell anemia and other hemoglobinopathies, as well as attendant peripheral vascular diseases.
Inventor(s):	Van Duzee; Barry F. (Cincinnati, OH)
Assignee:	The Procter & Gamble Company (Cincinnati, OH)
Application Number:	05/732,226
Patent Claims:	1. A process for treating sickle cell anemia comprising administering to patients in need of such treatment a safe and effective amount of a geminal diphosphonate compound. 2. A process according to claim 1 wherein the geminal diphosphonate compound is a member selected from the group consisting of ethane-1-hydroxy-1,1-diphosphonic acid, and the pharmaceutically-acceptable salts and esters thereof. 3. A process according to claim 2 wherein the geminal diphosphonate compound is a sodium salt of ethane-1-hydroxy-1,1-diphosphonic acid. 4. A process according to claim 1 wherein the geminal diphosphonate compound is a member selected from the group consisting of methanediphosphonic acid, and the pharmaceutically-acceptable salts and esters thereof. 5. A process according to claim 1 wherein the geminal diphosphonate compound is a member selected from the group consisting of methanedichlorodiphosphonic acid, and the pharmaceutically-acceptable salts and esters thereof.