You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 23, 2024

Claims for Patent: 4,278,689

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,278,689

Title:	1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
Abstract:	This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Inventor(s):	Murdock; Keith C. (Pearl River, NY), Durr; Frederick E. (Ridgewood, NJ)
Assignee:	American Cyanamid Company (Stamford, CT)
Application Number:	06/063,285
Patent Claims:	1. A pharmaceutical composition in dosage unit form comprising from about one to about 30 mg. of a compound selected from the group consisting of those of the formula: ##STR11## wherein Q is a divalent moiety selected from the group consisting of those of the formulae: ##STR12## wherein n is an integer from 2 to 4, inclusive; R.sub.1 and R.sub.2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group with the proviso that R.sub.1 and R.sub.2 may not both be hydrogen or alkyl; and the pharmacologically acceptable acid-addition salts thereof; in association with a pharmaceutical carrier. 2. A composition according to claim 1 wherein the compound is a salt of sulfuric acid. 3. A composition according to claim 1 wherein the compound is a salt of hydrochloric acid. 4. A composition according to claim 1 wherein the compound is a salt of sulfamic acid. 5. A composition according to claim 1 wherein the compound is a salt of citric acid. 6. A composition according to claim 1 wherein the compound is a salt of lactic acid. 7. A composition according to claim 1 wherein the compound is a salt of succinic acid. 8. A composition according to claim 1 wherein the compound is a salt of acetic acid. 9. A composition according to claim 1 wherein the compound is a salt of gluconic acid. 10. The composition according to claim 1 wherein Q is ethylene and R.sub.1 and R.sub.2 are both .beta.-hydroxyethyl and in the aromatic free base form. 11. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the disuccinate salt form. 12. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the dihydrochloride salt form. 13. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is 3-hydroxypropyl and in the dihydrobromide salt form. 14. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is 2-hydroxypropyl and in the disuccinate salt form. 15. The composition according to claim 1 wherein Q is trimethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the diacetate salt form. 16. The composition according to claim 1 wherein Q is --CH.sub.2 CH(CH.sub.3)--, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the dimalate salt form. 17. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the aromatic free base form. 18. A composition according to claim 17 in its pharmacologically acceptable acid-addition salt form. 19. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the digluconate salt form. 20. The composition according to claim 1 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the dibenzoate salt form. 21. A pharmaceutical composition in dosage unit form comprising from about one to about 30 mg. of a compound selected from the group consisting of those of the formula: ##STR13## wherein Q is a divalent moiety selected from the group consisting of those of the formulae: ##STR14## wherein n is an integer from 2 to 4, inclusive; R.sub.1 and R.sub.2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group with the proviso that R.sub.1 and R.sub.2 may not both be hydrogen or alkyl; and the pharmacologically acceptable acid-addition salts thereof; in association with a pharmaceutical carrier. 22. A composition according to claim 21 wherein the compound is a salt of phosphoric acid. 23. A composition according to claim 21 wherein the compound is a salt of hydrobromic acid. 24. A composition according to claim 21 wherein the compound is a salt of malic acid. 25. A composition according to claim 21 wherein the compound is a salt of tartaric acid. 26. A composition according to claim 21 wherein the compound is a salt of benzoic acid. 27. A composition according to claim 21 wherein the compound is a salt of ascorbic acid. 28. The composition according to claim 21 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is .beta.-hydroxyethyl and in the leuco free base form. 29. The composition according to claim 21 wherein Q is ethylene, R.sub.1 is hydrogen, and R.sub.2 is 2-hydroxypropyl and in the leuco free base form.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.