Claims for Patent: 4,314,081
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Summary for Patent: 4,314,081
| Title: | Arloxyphenylpropylamines |
| Abstract: | 3-Aryloxy-3-phenylpropylamines and acid additions salts thereof, useful as psychotropic agents, particularly as anti-depressants. |
| Inventor(s): | Molloy; Bryan B. (Indianapolis, IN), Schmiegel; Klaus K. (Indianapolis, IN) |
| Assignee: | Eli Lilly and Company (Indianapolis, IN) |
| Application Number: | 05/432,379 |
| Patent Claims: |
1. A compound of the formula ##STR7## wherein each R' is independently H or CH.sub.3 and R is m- or p-chlorophenyl, o-, m-, or p-methoxyphenyl, phenyl, o- or m-fluorophenyl, o- or
p-tolyl, 2,4-difluorophenyl or p-trifluoromethylphenyl and acid addition salts formed with pharmaceutically-acceptable acids.
2. A compound according to claim 1, said compound being N-methyl 3-(o-tolyloxy)-3-phenylpropylamine and pharmaceutically-acceptable acid addition salts thereof. 3. A compound according to claim 2, said compond being N-methyl 3-(o-tolyloxy)-3-phenylpropylamine hydrochloride. 4. A compound according to claim 1, said compound being N-methyl 3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, and pharmaceutically-acceptable acid addition salts thereof formed with non-toxic acids. 5. A compound according to claim 4, said compound being N-methyl 3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride. 6. A compound according to claim 1, said compound being N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine, and pharmaceutically-acceptable acid addition salts thereof formed with non-toxic acids. 7. A compound according to claim 1, said compound being N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride. 8. A compound according to claim 1, said compound being N-methyl 3-(2,4-difluorophenoxy)-3-phenylpropylamine. 9. A compound according to claim 8, said compound being N-methyl 3-(m-fluorophenoxy)-3-phenylpropylamine oxalate. |
