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Last Updated: November 4, 2024

Claims for Patent: 4,391,802

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Summary for Patent: 4,391,802

Title:	Method of treating leukemia or leukemoid diseases
Abstract:	A method of leukemia or leukemoid disease treatment by administration of a vitamin D derivative with a hydroxyl group at 1.alpha.-position is disclosed. It is believed that the vitamin D derivative with a hydroxyl group at 1.alpha.-position is capable of treating cancer through redifferentiation of cancer cells and that this capability is inherent in vitamin D derivatives with a hydroxyl group at 1.alpha.-position.
Inventor(s):	Suda; Tatsuo (Tachikawa, JP), Hirasawa; Yoshihei (Niigata, JP), Takahashi; Sachio (Niigata, JP), Abe; Etsuko (Tokyo, JP), Konno; Kunio (Tokyo, JP), Aoki; Tadao (Niigata, JP)
Assignee:	Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:	06/356,385
Patent Claims:	1. A method for the treatment of leukemia or leukemoid diseases, comprising administering to a patient having such a disease an effective amount of a vitamin D derivative with a hydroxyl group at the 1.alpha.-position. 2. A method according to claim 1 wherein said derivative is administered in a soft capsule. 3. A method according to claim 1 wherein said derivative is administered in a daily dose of 0.5 to 5 .mu.g. 4. A method according to claim 1 for the treatment of leukemia, wherein the patient has leukemia. 5. A method according to claim 4 wherein the leukemia is a myelogenous leukemia. 6. A method according to claim 1 wherein said derivative is 1.alpha.-hydroxyvitamin D.sub.3. 7. A method according to claim 1 wherein said derivative is 1.alpha.,25-dihydroxyvitamin D.sub.3. 8. A method in accordance with claim 1, wherein said derivative is 1.alpha.-hydroxyvitamin D.sub.3, 1.alpha.,25-dihydroxyvitamin D.sub.3 or a mixture thereof.

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