Claims for Patent: 4,451,458

Summary for Patent: 4,451,458

Title:	Method for the treatment of post-operative thrombosis
Abstract:	The invention provides novel pharmaceutical compositions useful in the treatment of thrombosis in mammals, comprising a mixture of dihydroergotamine or a related ergot alkaloid and heparin.
Inventor(s):	Buhlmann; Hans (Nuremberg, DE), Welzel; Dieter (Nuremberg, DE)
Assignee:	Sandoz Ltd. (Basel, CH)
Application Number:	06/379,272
Patent Claims:	1. A method for the prophylactic treatment of post-operative thrombosis in mammals, comprising parenterally administering dihydroergotamine in conjunction with heparin, wherein the administration is effected with a unit dose comprising about 0.5 mg. of dihydroergotamine and about 2500-5000 I.U. of heparin and said doses are administered two to four times daily. 2. A pharmaceutical composition useful in the prophylactic treatment of post-operative thrombosis in mammals, comprising in unit dosage form about 0.5 mg. of dihydroergotamine and about 2500-5000 I.U. of heparin. 3. A pharmaceutical composition useful in the prophylactic treatment of post-operative thrombosis in mammals, comprising in unit dosage form about 0.5 mg. of dihydroergotamine and about 5000 I.U. of heparin.