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Last Updated: March 30, 2025

Claims for Patent: 4,526,892

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Summary for Patent: 4,526,892

Title:	Dimethylaminoalkyl-3-(ergoline-8'.beta.carbonyl)-ureas
Abstract:	Novel ergoline derivatives formed by reaction of an 8-carboxy ergoline with a carbodiimide and having hypotensive and antiprolatinic activity.
Inventor(s):	Salvati; Patricia (Milan, IT), Caravaggi; Anna M. (Milan, IT), Temperilli; Aldemio (Milan, IT), Bosisio; Germano (Milan, IT), Sapini; Osvaldo (Gallarate, IT), di Salle; Enrico (Milan, IT)
Assignee:	Farmitalia Carlo Erba, S.p.A. (Milan, IT)
Application Number:	06/448,364
Patent Claims:	1. Compounds of formula ##STR3## wherein R.sub.1 is a hydrogen atom or a methyl group; R.sub.2 is a hydrogen atom; R.sub.3 is a hydrogen atom or a methoxy group; R.sub.4 is an alkyl or an alkenyl group selected from methyl, allyl and propyl groups; and each of R.sub.5 and R.sub.6 independently is an alkyl group having from 1 to 3 carbon atoms or a group of the formula (CH.sub.2).sub.n N(CH.sub.3).sub.2 in which n is 3 with the proviso that at least one of R.sub.5 and R.sub.6 is said dimethylaminoalkyl group, and pharmaceutically acceptable addition salts with organic or inorganic acid thereof. 2. A compound according to claim 1 which is selected from the group consisting of: 1-ethyl-3-(3'-dimethylaminopropyl)-3(6'-methylergoline-8'.beta.-carbonyl)-u rea; 1-ethyl-3-(3'-dimethylaminopropyl)-3-(10'.alpha.-methoxy-6'-methylergoline- 8'.beta.-carbonyl)-urea; 1-(3'-dimethylaminopropyl)-3-ethyl-3-(6'-allylergoline-8'.beta.-carbonyl)-u rea; and 1-ethyl-3-(3'-dimethylaminopropyl)-3-(6'-n-propylergoline-8'.beta.-carbonyl )-urea. 3. A pharmaceutical composition containing a therapeutically effective amount of a compound according to claim 1, in admixture with a pharmaceutically acceptable carrier for oral or parenteral administration. 4. 1-ethyl-3-(3'dimethylaminopropyl)-3-(6'-allylergoline-8'.beta.-carbonyl) -urea.

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