Claims for Patent: 4,703,063
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Summary for Patent: 4,703,063
| Title: | Sulfamoyl substituted phenethylamine derivatives and process of producing them |
| Abstract: | Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure. |
| Inventor(s): | Imai; Kazuo (Saitama, JP), Niigata; Kunihiro (Saitama, JP), Fujikura; Takashi (Saitama, JP), Hashimoto; Shinichi (Chiba, JP), Takenaka; Toichi (Tokyo, JP) |
| Assignee: | Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP) |
| Application Number: | 06/756,790 |
| Patent Claims: |
1. Sulfamoyl-substituted phenethylamine derivatives represented by the general formula ##STR79## wherein R.sub.1 represents an amino group or a mono- or di-lower alkylamino
group; R.sub.2 represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom, a lower alkoxy group or a lower alkyl group; R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, and R.sub.9 each represents a
hydrogen atom or a lower alkyl group; R.sub.10 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom, and the salts thereof.
2. A pharmaceutical composition containing an effective .alpha.-adrenergic antagonistic amount of a compound of claim 1 and a pharmaceutically acceptable excipient. 3. The salts of the sulfamoyl-substituted phenethylamine derivatives as claimed in claim 1 wherein R.sub.3 is a lower alkyl group or a lower alkoxy group. 4. The compound of claim 1 wherein R.sub.3 is a hydrogen atom and the salts thereof. 5. The compound of claim 1 wherein R.sub.3 is a lower alkyl group and the salts thereof. 6. The compound of claim 1 which is a racemic compound. 7. The compound of claim 1 which is a mixture of racemic compounds. 8. The compound of claim 1 which is an optically active isomer. 9. The isomer of claim 8 which is the (+) isomer. 10. The isomer of claim 8 which is the (-) isomer. 11. The optically active isomers of the compound of claim 7. 12. The isomer of claim 11 which is the (+) isomer. 13. The isomer of claim 11 which is the (-) isomer. 14. The compound of claim 1 which is 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenzenesulfon amide. 15. The compound of claim 1 which is 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}benzenesulfo namide. 16. The compound of claim 1 which is 5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-2-methylbenzenesulfon amide. 17. The compound of claim 1 which is 5-{2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide. 18. The compound of claim 1 which is 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-N-methylben zenesulfonamide. 19. The compound of claim 1 which is 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-N,N-dimethy lbenzenesulfonamide. |
