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Last Updated: November 23, 2024

Claims for Patent: 4,721,723

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Summary for Patent: 4,721,723

Title:	Anti-depressant crystalline paroxetine hydrochloride hemihydrate
Abstract:	The invention provides crystalline paroxetine hydrochloride hemihydrate, processes for its preparation, compositions containing the same and its therapeutic use as an anti-depressant.
Inventor(s):	Barnes; Roger D. (Betchworth, GB2), Wood-Kaczmar; Marian W. (Harlow, GB2), Curzons; Alan D. (Worthing, GB2), Lynch; Ian R. (Epsom, GB2), Richardson; John E. (Harlow, GB2), Buxton; Philip C. (Epsom, GB2)
Assignee:	Beecham Group p.l.c. (Brentford, GB2)
Application Number:	06/922,530
Patent Claims:	1. Crystalline paroxetine hydrochloride hemihydrate. 2. Crystalline paroxetine hydrochloride hemihydrate in substantially pure form. 3. Crystalline paroxetine hydrochloride hemihydrate, having substantially the same X-ray diffractogram as set out in FIG. 1, substantially the same IR spectrum, in a Nujol mull, as set out in FIG. 2, and substantially the same DSC profile as set out in FIG. 3. 4. A process for the preparation of crystalline paroxetine hydrochloride hemihydrate, which process comprises forming a solution of paroxetine hydrochloride and crystallizing said hemihydrate from solution by precipitation or recrystallization. 5. An anti-depressant pharmaceutical composition comprising an effective anti-depressant amount of crystalline paroxetine hydrochloride hemihydrate and a pharmaceutically acceptable carrier. 6. A method of treatment of depression in mammals, which method comprises administering an effective amount of crystalline paroxetine hydrochloride hemihydrate.

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