You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: November 22, 2024

Claims for Patent: 4,797,405

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,797,405

Title:	Stabilized pergolide compositions
Abstract:	Pharmaceutical compositions containing pergolide or a salt thereof stabilized to decomposition by light by incorporation therewith of a stabilizing agent selected from polyvinylpyrrolidone, .alpha.-tocopherol succinate and propyl gallate.
Inventor(s):	Conine; James W. (Indianapolis, IN), Stowers; Julian L. (Indianapolis, IN)
Assignee:	Eli Lilly and Company (Indianapolis, IN)
Application Number:	07/112,360
Patent Claims:	1. A pharmaceutical composition of pergolide or a salt thereof stabilized to decomposition by light comprising a therapeutically effective amount of pergolide or a salt thereof, a stabilizing agent selected from polyvinylpyrrolidone, .alpha.-tocopherol succinate and propyl gallate in an amount sufficient to effect stabilization to decomposition by light and pharmaceutically acceptable excipients. 2. The pharmaceutical composition of claim 1 wherein the pergolide is present as pergolide mesylate. 3. The pharmaceutical composition of claim 2 wherein the stabilizing agent is polyvinylpyrrolidone. 4. The pharmaceutical composition of claim 3 wherein the polyvinylpyrrolidone is present in said composition in an amount of from 0.3 to 2 percent by weight of the total composition. 5. The pharmaceutical composition of claim 4 wherein the polyvinylpyrrolidone is present in said composition in an amount of from 0.5 to 1.5 percent by weight of the total composition. 6. A method of stabilizing a pharmaceutical composition of pergolide or a salt thereof to decomposition by light comprising incorporating into said pharmaceutical composition, in addition to a therapeutically effective amount of said pergolide or a salt thereof and pharmaceutically acceptable excipients, a stabilizing agent selected from polyvinylpyrrolidone, .alpha.-tocopherol succinate and propyl gallate in an amount sufficient to effect stabilization to decomposition by light. 7. The method of claim 6 wherein the pergolide is present as pergolide mesylate. 8. The method of claim 7 wherein the stabilizing agentis polyvinylpyrrolidone. 9. The method of claim 8 wherein the polyvinylpyrrolidone is present in an amount of from 0.3 to 2 percent by weight of the total composition. 10. The method of claim 9 wherein the polyvinylpyrrolidone is present in an amount of from 0.5 to 1.5 percent by weight of the total composition.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.