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Last Updated: December 22, 2024

Claims for Patent: 4,808,614

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Summary for Patent: 4,808,614

Title:	Difluoro antivirals and intermediate therefor
Abstract:	A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
Inventor(s):	Hertel; Larry W. (Indianapolis, IN)
Assignee:	Eli Lilly and Company (Indianapolis, IN)
Application Number:	07/058,219
Patent Claims:	1. A nucleoside of the formula ##STR11## wherein R is a base selected from the group consisting of ##STR12## wherein R.sup.1 is hydrogen, methyl, bromo, fluoro, chloro oriodo; R.sup.2 is hydroxy; R.sup.3 is hydrogen, bromo, chloro or iodo. 2. A nucleoside of claim 1 wherein the carbohydrate moiety is in the ribose form. 3. A nucleoside of claim 2 wherein the base is of the formula ##STR13## 4. A nucleoside of claim 1 wherein the base is of the formula ##STR14## 5. A nucleoside of claim 4 wherein R.sup.1 is methyl. 6. A nucleoside of claim 3 wherein R.sup.1 is methyl. 7. A nucleoside of claim 1 wherein the base is of the formula ##STR15## 8. A nucleoside of claim 2 wherein the base is of the formula ##STR16## 9. A nucleoside of claim 7 wherein R.sup.1 is iodo. 10. A nucleoside of claim 8 wherein R.sup.1 is iodo. 11. A nucleoside of claim 7 wherein R.sup.1 is hydrogen. 12. A nucleoside of claim 8 wherein R.sup.1 is hydrogen. 13. A method of treating Herpes viral infections in mammals comprising administering to a mammal in need of such treatment an anti-Herpes viral effective amount of a compound of claim 1. 14. A pharmaceutical composition useful for treating Herpes viral infections comprising an anti-Herpes viral effective amount of a compound of claim 1 and a pharmaceutically-acceptable carrier, diluent or excipient therefor.

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