Claims for Patent: 4,879,288
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Summary for Patent: 4,879,288
| Title: | Novel dibenzothiazepine antipsychotic |
| Abstract: | 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4 ]thiazepine is disclosed as a neuroleptic with a much reduced incidence of side effects such as acute dystonia and dyskinesia and tardive diskinesia. |
| Inventor(s): | Warawa; Edward J. (Wilmington, DE), Migler; Bernard M. (Cherry Hill, NJ) |
| Assignee: | ICI Americas Inc. (Wilmington, DE) |
| Application Number: | 07/028,473 |
| Patent Claims: |
1. A compound of formula II ##STR14## and acid addition salts thereof.
2. A compound as claimed in claim 1 wherein said acid addition salts are phamaceutically acceptable acid addition salts. 3. A compound as claimed in claim 2 wherein said salt is a hemifumarate salt. 4. A compound as claimed in claim 2 wherein said salt is a hydrochloride salt. 5. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to manage a psychotic condition in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier. 6. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to reduce hyperactivity in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier. 7. A method of treating psychosis in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2. 8. A method of treating hyperactivity in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2. |
