Claims for Patent: 4,879,288

Summary for Patent: 4,879,288

Title:	Novel dibenzothiazepine antipsychotic
Abstract:	11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4 ]thiazepine is disclosed as a neuroleptic with a much reduced incidence of side effects such as acute dystonia and dyskinesia and tardive diskinesia.
Inventor(s):	Warawa; Edward J. (Wilmington, DE), Migler; Bernard M. (Cherry Hill, NJ)
Assignee:	ICI Americas Inc. (Wilmington, DE)
Application Number:	07/028,473
Patent Claims:	1. A compound of formula II ##STR14## and acid addition salts thereof. 2. A compound as claimed in claim 1 wherein said acid addition salts are phamaceutically acceptable acid addition salts. 3. A compound as claimed in claim 2 wherein said salt is a hemifumarate salt. 4. A compound as claimed in claim 2 wherein said salt is a hydrochloride salt. 5. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to manage a psychotic condition in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier. 6. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to reduce hyperactivity in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier. 7. A method of treating psychosis in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2. 8. A method of treating hyperactivity in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2.