Claims for Patent: 4,916,163

Summary for Patent: 4,916,163

Title:	Spray-dried lactose formulation of micronized glyburide
Abstract:	An improved, more bioavailable formulation of glyburide is provided which consists preponderantly by weight of spray-dried lactose is described. This formulation utililzes micronized glyburide, but is more economically manufacatured than heretofore known micronized glyburide formulations.
Inventor(s):	Ni; Philip F. (Texas Township, MI)
Assignee:	The Upjohn Company (Kalamazoo, MI)
Application Number:	06/741,241
Patent Claims:	1. In an micronized glyburide anti-diabetic pharmaceutical composition as a unit dose, containing one or more pharmaceutically acceptable excipients, the improvement which comprises: spray-dried lactose as the preponderant excipient in said composition, being present therein at about not less that seventy percent (70%) by weight of the final composition. 2. The improvement according to claim 1 wherein the micronized glyburide has a surface area of about 5 m.sup.2 /g. 3. The improvement according to claim 1 wherein the excipients comprise a glidant, lubricant and disintegrant. 4. The improvement according to claim 1 wherein the excipients comprise corn starch, silicon dioxide, and magnesium stearate.