Claims for Patent: 4,954,348

Summary for Patent: 4,954,348

Title:	Non-ionic polyol contrast media from ionic contrast media
Abstract:	Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
Inventor(s):	Sovak; Milos (Rancho Santa Fe, CA), Ranganathan; Ramachandran (Princeton, NJ)
Assignee:	Cook Imaging Corporation (Bloomington, IN)
Application Number:	07/214,663
Patent Claims:	1. A contrast medium formulation comprising 5-(N-2,3-dihydroxypropylacetamido)-2,4,6-triiodo-N-(23-dihydroxypropyl)-N' -(2-hydroxyethyl)-isophthalamide in a physiologically acceptable medium at a concentration in the range of about 50 to 400 mg I/ml. 2. 5-(N-b 2,3-dihydroxypropylacetamido)-2,4,6-triiodo-N-(2-3,-dihydroxypropyl)-N'-( 2-hydroxyethyl)-isophthalamide.