Claims for Patent: 4,983,598
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Summary for Patent: 4,983,598
| Title: | Pharmaceutical composition containing diltiazem and angiotensin-converting enzyme inhibitor |
| Abstract: | Compositions of diltiazem and angiotensin-converting enzyme inhibitor useful for the treatment of hypertension, cardiac insufficiency and coronary insufficiency. |
| Inventor(s): | Cavero; Icilio (Creteil, FR), Elkik; Francois (Paris, FR), Hicks; Peter (Cachan, FR), Muller; Jean-Claude (Morsang S/Orge, FR) |
| Assignee: | Synthelabo (Paris, FR) |
| Application Number: | 07/195,151 |
| Patent Claims: |
1. A pharmaceutical composition containing a combination of 10-360 mg of diltiazem and 1-100 mg of an angiotensin-converting enzyme inhibitor, enalapril useful for the
treatment of hypertension, cardiac insufficiency, and coronary insufficiency, such that the anti-hypertensive effect observed upon combined administration of diltiazem and said angiotensin-converting enzyme inhibitor is greater than the sum of the
individual anti-hypertensive effects observed upon the separate administration of diltiazem and said angiotensin-converting enzyme inhibitor alone.
2. A method for treatment of hypertension, cardiac insufficiency or coronary insufficiency comprising administering to a subject suffering therefrom a pharmaceutical composition containing a combination of 10 to 360 mg of diltiazem and 1 to 100 mg of an angiotensin-converting enzyme inhibitor, enalapril, such that the anti-hypertenive effect observed upon administration of the combined administration of diltiazem and said angiotensin-converting enzyme inhibitor is greater than the sum of the individual anti-hypertensive effects observed upon the separate administration of diltiazem and said angiotensin-converting enzyme inhibitor alone. |
