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Last Updated: November 22, 2024

Claims for Patent: 5,013,743

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Summary for Patent: 5,013,743

Title:	Selective antibacterial agent against campytobacter
Abstract:	The compound represented by the formula; ##STR1## [wherein R.sup.1 stands for hydrogen, methoxy or trifluoromethyl; R.sup.2 and R.sup.3, being the same or different from each other, stand for hydrogen or methyl; R.sup.4 stands for optionally substituted hydrocarbon residue; and n denotes 0 or 1] or a salt thereof show excellent antibacterial activities, against the genus Campylobacter, especially against Campylobacter pylori, and they are used for preventing or treating infectious diseases caused by the said bacteria.
Inventor(s):	Iwahi; Tomoyuki (Suita, JP), Satoh; Hiroshi (Suita, JP)
Assignee:	Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:	07/478,405
Patent Claims:	1. A method for combatting infectious diseases caused by the genus campylobater which comprises administering to a mammal in need thereof an antibiotially-effective amount of a compound of the formula ##STR3## wherein R.sup.1 stands for hydrogen, methoxy or triflouromethyl; R.sup.2 and R.sup.3, being the same or different from each other, stand for hydrogen or methyl; and R.sup.4 stands for optionally substituted hydrocarbon residue and n denotes 0 or 1, or a pharmacologically acceptable salt thereof. 2. A method according to claim 1, wherein R.sup.1 is hydrogen. 3. A method according to claim 1, wherein R.sup.3 is hydrogen. 4. A method according to claim 1, wherein R.sup.4 is fluorinated alkyl group. 5. A method according to claim 1, wherein R.sup.4 is fluorinated alkyl group. 6. A method according to claim 1, wherein R.sup.1 is fluorinated alkyl group. 7. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl}methylsulfinylbenzimidazol e. 8. A method according to claim l, wherein the compound is 2-{3-methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl}methylthiobenzimidazole. 9. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyrid-2-yl}methylsulfinylbenzi midazole. 10. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyrid-2-yl}methylthiobenzimida zole. 11. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3-tetrafluoropropoxy)pyrid-2-yl}methylsulfinylbenzimi dazole. 12. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3-tetrafluoropropoxy)pyrid-2-yl}methylthiobenzimidazo le. 13. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,4,4-hexafluorobutyloxy)pyrid-2-yl}methylsulfinylben zimidazole. 14. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,4,4-hexafluorobutyloxy)pyrid-2-yl}methylthiobenzimi dazole. 15. A method according to claim 1, wherein the compound is 2-(3,5-dimethyl-4-methoxypyrid-2-yl)methylsulfinyl-5-methoxybenzimidazole.

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