You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 22, 2024

Claims for Patent: 5,036,102


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 5,036,102
Title: Method of treating autoimmune diseases comprising administration of psoralen dosage forms
Abstract:A method of treating leukocyte mediated autoimmune and skin diseases using psoralen reagent composition comprising sterile aqueous solutions suitable for extracorporeal administration to blood from a subject being treated by ultraviolet-A photophoresis.
Inventor(s): Bachynsky; Maria O. (Nutley, NJ), Infeld; Martin H. (Upper Montclair, NJ), Margolis; Richard J. (Wayne, NJ), Perla; Dennis A. (Wayne, NJ)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:07/582,467
Patent Claims: 1. A method for the therapy of leukocyte mediated diseases comprising extracorporeal administration to the blood of a subject undergoing ultraviolet-A photophoresis prior to reinfusion of the blood into said subject a composition comprising a sterile aqueous solution of about 0.005 mg/ml to about 1 mg/ml of a psoralen, ethyl alcohol, propylene glycol and water, said composition having a pH from about 2.0 to about 5.5.

2. The method of claim 1 wherein the leukocyte mediated condition is selected from the group consisting of Scleroderma, Systemic Lupus Erythematosis (SLE) Psoriasis, Pemphigus, Psoriatic Arthritis, Atopic Dermatitis, Rheumatoid Arthritis, Multiple Sclerosis.

3. The method of claim 1 wherein the psoralen is 8-MOP.

4. The method of claim 3 wherein the 8-MOP is administered to the patient's blood just after it is withdrawn from the patient and prior to its separation into leukocyte rich and leukocyte poor fractions.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.