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Last Updated: December 22, 2024

Claims for Patent: 5,041,424

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Summary for Patent: 5,041,424

Title:	Epipodophyllotoxin glucoside 4'-phosphate derivatives
Abstract:	Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.
Inventor(s):	Saulnier; Mark G. (Middletown, CT), Senter; Peter D. (Seattle, WA), Kadow; John F. (Meriden, CT)
Assignee:	Bristol-Myers Company (New York, NY)
Application Number:	07/450,718
Patent Claims:	1. A method for inhibiting mammalian tumor said tumor being sensitive to etoposide or teniposide which comprises administering to a mammal in need thereof an antitumour effective amount of a compound of the formula ##STR10## wherein R.sup.1 is methyl or 2-thienyl, and R.sup.6 is H; or a pharmaceutically acceptable salt thereof. 2. A method according to claim 1 wherein said compound is etoposide 4'-phosphate disodium salt.

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