Claims for Patent: 5,225,183
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Summary for Patent: 5,225,183
| Title: | Medicinal aerosol formulations |
| Abstract: | A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane. |
| Inventor(s): | Purewal; Tarlochan S. (Leamington Spa, GB2), Greenleaf; David J. (Loughborough, GB2) |
| Assignee: | Riker Laboratories, Inc. (St. Paul, MN) |
| Application Number: | 07/649,140 |
| Patent Claims: |
1. An aerosol formulation comprising:
(a) a therapeutically effective amount of a medicament; (b) a propellant substantially free of chlorofluorocarbons, said propellant comprising 1,1,1,2-tetrafluoroethane; (c) a surface active agent in an amount sufficient (i) to stabilize the formulation or (ii) lubricate a valve stem in a metering valve; and (d) at least one compound selected from the group consisting of ethyl alcohol, isopropyl alcohol, n-pentane, isopentane, neopentane, isopropyl, and myristate, said compound being present in an amount such that it is miscible with the 1,1,1,2-tetrafluoroethane and such that said surface active agent is soluble in the formulation in a greater amount than in 1,1,1,2-tetrafluoroethane. 2. The formulation of claim 1 wherein the weight ratio of 1,1,1,2-tetrafluoroethane to compound (d) is in the range of 50:50 to 99:1. 3. The formulation of claim 1 wherein said medicament is a member selected from the group consisting of salbutamol, beclomethasone dipropionate, disodium cromoglycate, pirbuterol, isoprenaline, adrenaline, rimiterol, and ipratropium bromide. |
