Claims for Patent: 5,229,382

Summary for Patent: 5,229,382

Title:	2-methyl-thieno-benzodiazepine
Abstract:	2-Methyl-10-(4-methyl-1-piperazinyl)-4H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR1##
Inventor(s):	Chakrabarti; Jiban K. (Frimley, GB2), Hotten; Terrence M. (Farnborough, GB2), Tupper; David E. (Reading, GB2)
Assignee:	Lilly Industries Limited (Basingstoke, GB2)
Application Number:	07/890,348
Patent Claims:	1. 2-Meth yl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof. 2. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable acid addition salt thereof together with a pharmaceutically acceptable diluent or carrier therefor. 3. A pharmaceutical composition in capsule or tablet form comprising from 2.5 to 5 mg of the compound of claim 1 together with a pharmaceutically acceptable diluent or carrier therefor. 4. A method of treating an animal, including a human, suffering from or susceptible to psychosis, acute mania or mild anxiety states, which comprises administering an effective amount of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof. 5. A method of claim 4 for treating an animal, including a human, suffering from or susceptible to psychosis. 6. A method of claim 5 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof. 7. A method of claim 5 for treating an animal, including a human, suffering from or susceptible to schizophrenia. 8. A method of claim 7 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition solution salt thereof. 9. A method of claim 5 for treating an animal, including a human, suffering from or susceptible to schizophreniform diseases. 10. A method of claim 9 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof. 11. A method of claim 4 for treating an animal, including a human, suffering from or susceptible to acute mania. 12. A method of claim 11 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof. 13. A method of claim 4 for treating an animal, including a human, suffering from or susceptible to mild anxiety states. 14. A method of claim 13 wherein the effective amount is from 0.1 to 20 mg per day of 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, or a pharmaceutically acceptable acid addition salt thereof. 15. A pharmaceutical composition in capsule or tablet form comprising from 0.1 to 20 mg of the compound of claim 1 together with a pharmaceutically acceptable diluent or carrier therefor.