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Last Updated: December 22, 2024

Claims for Patent: 5,336,691

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Summary for Patent: 5,336,691

Title:	Composition comprising a tramadol material and acetaminophen and its use
Abstract:	This invention relates to a composition comprising a tramadol material and acetaminophen, and its use. As used herein tramadol refers to various forms of tramadol. The compositions are pharmacologically useful in treating pain and tussive conditions. The compositions are also subject to less opioid side-effects such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, where the components of the compositions are within certain ratios the pharmacological effects of the compositions are superadditive (synergistic).
Inventor(s):	Raffa; Robert B. (Norristown, PA), Vaught; Jeffrey L. (Perkosie, PA)
Assignee:	McNeilab, Inc. (Spring House, PA)
Application Number:	07/974,865
Patent Claims:	1. A pharmaceutical composition comprising a tramadol material and acetaminophen, wherein the ratio of the tramadol material to acetaminophen is a weight ratio from about 1:1 to about 1:1600. 2. The pharmaceutical composition of claim 1 wherein the tramadol material is tramadol hydrochloride. 3. The pharmaceutical composition of claim 2 wherein the tramadol hydrochloride is racemic. 4. The pharmaceutical composition of claim 1 wherein the weight ratio is about 1:1. 5. The pharmaceutical composition of claim 1 wherein the weight ratio is from about 1:5 to about 1:1600. 6. The pharmaceutical composition of claim 5 wherein the weight ratio is about 1:5. 7. The pharmaceutical composition of claim 5 wherein the weight ratio is from about 1:19 to about 1:800. 8. The pharmaceutical composition of claim 7 wherein the weight ratio is from about 1:19 to about 1:50. 9. The pharmaceutical composition of claim 1 further comprising a pharmaceutically acceptable carrier. 10. The pharmaceutical composition of claim 1 further comprising a decongestant or bronchodilator. 11. The pharmaceutical composition of claim 1 further comprising an antitussive. 12. The pharmaceutical composition of claim 1 further comprising an antihistamine or a non-sedating antihistamine. 13. The pharmaceutical composition of claim 1 further comprising a muscle relaxant. 14. The pharmaceutical composition of claim 1 further comprising a sleep aid. 15. A method for treating a pain in a mammal comprising an administration to the mammal an effective amount of the pharmaceutical composition of claim 1.

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