Claims for Patent: 5,418,226
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Summary for Patent: 5,418,226
| Title: | Monoquaternary 2,16-bispiperidinylandrostane derivatives |
| Abstract: | Monoquaternary 2,16-bispiperidinylandrostane neuromuscular blocking derivatives having the formula: ##STR1## wherein R.sub.1 is ethyl; R.sub.2 is methyl or allyl; and X.sup.- is a pharmaceutically acceptable anion; or pharmaceutically acceptable salts thereof. |
| Inventor(s): | Sleigh; Thomas (Wishaw, GB6), Carlyle; Ian C. (Hamilton, GB6), Muir; Alan W. (Ravenstruther, GB6) |
| Assignee: | Akzo N.V. (Arnhem, NL) |
| Application Number: | 08/048,539 |
| Patent Claims: |
1. A monoquaternary 2,16-bispiperidinylandrostane derivative having the formula: ##STR4## wherein R.sub.1 is ethyl;
R.sub.2 is methyl or allyl; and X.sup.- is a pharmaceutically acceptable anion; or a pharmaceutically acceptable salt thereof. 2. The monoquaternary 2,16-bispiperidinylandrostane derivative of claim 1, wherein R.sub.1 is ethyl, R.sub.2 is allyl and X is a pharmaceutically acceptable anion; or a pharmaceutically acceptable salt thereof. 3. The monoquaternary 2,16-bispiperidinylandrostane derivative of claim 1, wherein X is Br.sup.-. 4. A pharmaceutical composition comprising an effective amount of the monoquaternary 2,16-bispiperidinylandrostane derivative of claim 1 to effect neuromuscular blocking activity and a pharmaceutically acceptable diluent or auxiliary. 5. A method for effecting neuromuscular blocking activity in a patient comprising administering an effective amount of the monoquaternary 2,16-bispiperidinylandrostane derivative of claim 1 to the patient. |
