Claims for Patent: 5,455,044

Summary for Patent: 5,455,044

Title:	Method for treating neurological disorders
Abstract:	A method for ameliorating a neurological disorder in a human by administration to the cerebrospinal fluid (CSF) of a therapeutic agent in a dispersion system which allows the therapeutic agent to persist in the cerebro-ventricular space.
Inventor(s):	Kim; Sinil (Solana Beach, CA), Howell; Stephen B. (Del Mar, CA)
Assignee:	DepoTech Corporation (LaJolla, CA)
Application Number:	08/062,799
Patent Claims:	1. A method for ameliorating a cell proliferative disease which comprises intralumbar administration to the cerebrospinal fluid (CSF) of a human with the disease of a therapeutically effective amount of an antitumor drug in a synthetic membrane vesicle such that the antitumor agent persists in the cerebro-ventricular space for a time sufficient to ameliorate the disease. 2. The method of claim 1, wherein the synthetic membrane vesicle is a liposome. 3. The method of claim 2, wherein the liposome contains multiple concentric chambers. 4. The method of claim 1, wherein the synthetic membrane vesicle contains multiple non-concentric chambers.