Claims for Patent: 5,474,756
✉ Email this page to a colleague
Summary for Patent: 5,474,756
Title: | Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
Abstract: | A method for imaging mammalian tissue utilizing a non-ionic complex of a paramagnetic ion of lanthanide element and a macrocyclic chelating agent. |
Inventor(s): | Tweedle; Michael F. (Hightstown, NJ), Gaughan; Glen T. (Oxford, GB2), Hagan; James J. (Holmdel, NJ) |
Assignee: | Bracco International B.V. (Amsterdam, NL) |
Application Number: | 08/359,960 |
Patent Claims: |
1. In a method for imaging mammalian tissue which comprises subjecting the patient to magnetic resonance imaging wherein said patient has been administered orally, intrathecally
or intravenously an effective amount of a contrast agent which is a stable complex of a paramagnetic ion of a lanthanide element and a tetraazacyclo compound, the improvement wherein said complex is charge neutral in aqueous solution.
2. A method according the claim 1 wherein the tetraazacyclo compound has the formula represented below ##STR24## or a pharmaceutically acceptable salt thereof, wherein Y is oxygen or ##STR25## R.sub.1 is hydrogen, alkyl having from one to five carbon atoms, arylalkyl wherein the aryl portion is phenyl or substituted phenyl, phenyl or substituted phenyl, alkoxy having from one to five carbon atoms, hydroxyalkyl wherein the alkyl portion has from one to five carbon atoms and having one or more hydroxy groups ##STR26## ##STR27## wherein G is NH.sub.2, ##STR28## NHR.sub.4, N(R.sub.4).sub.2, CN, wherein R.sub.4 is alkyl or hydroxyalkyl, ##STR29## wherein n and m are zero or an integer from one to five, R.sub.2 is hydrogen or alkyl, R.sub.3 is hydrogen, hydroxyalkyl having from one to five carbon atoms and having one or more hydroxy groups, alkoxy having from one to five carbon atoms, phenyl or substituted phenyl or phenylalkyl or substituted phenylalkyl and X is chloro, bromo or iodo, wherein the term substituted phenyl refers to phenyl groups substituted with one, two or three halogen, hydroxyl, alkyl, alkoxy carbamoyl or carboxyl groups. 3. The method of claim 1 wherein said tetraazacyclo compound is a tetraazacyclododecane. |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.