Claims for Patent: 5,482,934

Summary for Patent: 5,482,934

Title:	Pregna-1,4-diene3,20-dione-16-17-acetal-21 esters, process for their preparation, composition, and methods for the treatment of inflammatory conditions
Abstract:	The present invention relates to compounds of the formula: ##STR1## in which X.sub.1 and X.sub.2 correspond to H or F without distinction; R.sub.1 represents the following radicals: ##STR2## and R.sub.2 represents the radicals ##STR3## in the form of an R epimer, an S epimer, or a stereoisomeric mixture of the R and S epimers in terms of the orientation of the substituents on the carbon atom at position 22, novel intermediates and a method of their preparation by hydrolysis-ketalization, and use of such compounds as drugs and/or therapeutic agents.
Inventor(s):	Calatayud; Jose (Madrid, ES), Conde; Jose R. (Madrid, ES), Luna; Manuel (Madrid, ES)
Assignee:	Especialidades Latinas Medicamentos Universales, S.A. (Elmu, S.A.) (Madrid, ES)
Application Number:	08/278,112
Patent Claims:	1. A compound of the formula ##STR20## in the form of an R epimer, an S epimer, or a stereoisomeric mixture of the R and S epimers in terms of the orientation of the substituents on the carbon atom at position 22, wherein: R.sub.1 is cyclohexyl, R.sub.2 is a member selected from the group consisting of ##STR21## and wherein X.sub.1 and X.sub.2 may be the same or different and each is a member selected from the group consisting of hydrogen and fluorine. 2. A compound according to claim 1 in the form of the (22S)- epimer. 3. A compound according to claim 1 in the form of the (22R)- epimer. 4. An anti-inflammatory drug containing a compound according to claim 1. 5. A method of treating inflammatory conditions which comprises administering to a patient an anti-inflammatory effective amount of a compound according to claim 1. 6. A pharmaceutical composition having anti-inflammatory properties comprising as the active ingredient an effective amount of a compound according to claim 1 together with a pharmaceutically acceptable carrier. 7. A method for the treatment and control of inflammatory conditions characterized by the topical administration to a patient of an effective dose of a compound according to claim 1. 8. The compound of claim 1 which is [11.beta.,16.alpha.(R,S)]-16,17-[cyclohexylmethylene)bis (oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione. 9. The R-epimer of the compound of claim 8. 10. The S-epimer of the compound of claim 8. 11. A compound of claim 1 wherein each of is X.sub.1 and X.sub.2 is hydrogen. 12. A compound of claim 1 wherein each of X.sub.1 and X.sub.2 is fluorine.