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Last Updated: November 23, 2024

Claims for Patent: 5,547,994

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Summary for Patent: 5,547,994

Title:	Method for treating asthma using optically pure R(-) albuterol
Abstract:	The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.
Inventor(s):	Barberich; Timothy J. (Concord, MA), Young; James W. (Still River, MA)
Assignee:	Sepracor, Inc. (Marlborough, MA)
Application Number:	08/335,480
Patent Claims:	1. A method of treating an acute attack of asthma, while reducing side effects associated with the acute administration of racemic albuterol, comprising administering to an individual suffering from an acute attack of asthma a quantity of an optically pure R(-) isomer of albuterol sufficient to result in bronchodilation while simultaneously reducing undesirable side effects, said R isomer being substantially free of its S(+) isomer. 2. A method of claim 1 wherein the amount of the R(-) isomer of albuterol is greater than approximately 90% by weight. 3. A method of claim 2 wherein the amount of the R(-) isomer of albuterol is greater than 99% by weight. 4. A method of claim 1 comprising administering to the individual by inhalation from approximately 30 mcg to approximately 90 mcg of the R(-) isomer of albuterol per dose. 5. A method of treating an acute attack of asthma, while reducing side effects associated with the acute administration of racemic albuterol, comprising administering to an individual suffering from an acute attack of asthma a quantity of an optically pure R(-) isomer of albuterol sufficient to result in bronchodilation while simultaneously reducing undesirable side effects, and at least one additional drug selected from the group consisting of bronchodilators, antihistamines and analgesics. 6. A method of claim 5 wherein the analgesic is selected from the group consisting of: aspirin, acetaminophen and ibuprofen.

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