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Last Updated: December 22, 2024

Claims for Patent: 5,552,394

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Summary for Patent: 5,552,394

Title:	Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy
Abstract:	A method of female contraception which is characterized by a reduced incidence of breakthrough bleeding after the first cycle involves monophasicly administering a combination of estrogen and progestin for 23-25 consecutive days of a 28 day cycle in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively and in which the weight ratio of estrogen to progestin is at least 1:45 calculated as ethinyl estradiol to norethindrone acetate.
Inventor(s):	Hodgen; Gary D. (Norfolk, VA)
Assignee:	The Medical College of Hampton Roads (Norfolk, VA)
Application Number:	08/279,300
Patent Claims:	1. A method of female contraception which is characterized by a reduced incidence of breakthrough bleeding after the first cycle which comprises monophasicly administering a combination of estrogen and progestin for 23-25 consecutive days of a 28 day cycle in which the daily amounts of estrogen and progestin are equivalent to about 1-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively, and in which the weight ratio of estrogen to progestin is at least 1:45 calculated as ethinyl estradiol to norethindrone acetate. 2. The method of claim 1 in which the daily amount of progestin is equivalent to 0.5-0.75 mg of norethindrone acetate. 3. The method of claim 2 in which the weight ratio is at least 1:50. 4. The method of claim 3 in which the combination is administered for 24 days of the 28 day cycle. 5. The method of claim 4 in which the estrogen is ethinyl estradiol. 6. The method of claim 5 in which the progestin is norethindrone acetate. 7. The method of claim 1 in which the daily amount of progestin is equivalent to 0.5-1.5 mg of norethindrone acetate. 8. The method of claim 1 in which the weight ratio is at least 1:50. 9. The method of claim 1 in which the combination is administered for 24 days of the 28 day cycle. 10. The method of claim 1 in which the estrogen is ethinyl estradiol. 11. The method of claim 1 in which the progestin is norethindrone acetate. 12. The method of claim 1 in which the daily amount of estrogen is up to 30 mcg of ethinyl estradiol.

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