Claims for Patent: 5,601,843
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Summary for Patent: 5,601,843
Title: | Pharmaceutical tablet composition |
Abstract: | A pharmaceutical composition including a core of an NSAID selected from diclofenac and piroxicam which core is surrounded by a mantle coating of a prostaglandin, wherein an intermediate coating can be present between the NSAID core and prostaglandin mantle coating. |
Inventor(s): | Gimet; Rene A. (Valbonne, FR), Jinot; Jean C. (Cagnes-sur-Mer, FR), Magnet; Christian (Chanceaux sur Choisille, FR), Maroteaux; Isabelle (Antibes, FR), Nevoux; Francoise M. (Evanston, IL), Scoyer; Roger E. (Jemeppe-sur-Sambre, BE), Struthers; Barbara J. (Deerfield, IL) |
Assignee: | G. D. Searle & Co. (Chicago, IL) |
Application Number: | 08/276,299 |
Patent Claims: |
1. A pharmaceutical tablet composition comprising:
a. a core consisting of a therapeutically-effective amount of a nonsteroidal anti-inflammatory agent selected from diclofenac and piroxicam; and b. a mantle coating surrounding the core comprising a therapeutically-effective amount of misoprostol. 2. A pharmaceutical composition as recited in claim 1 wherein the NSAID comprises diclofenac. 3. A pharmaceutical composition as recited in claim 1 wherein the NSAID comprises piroxicam. 4. A pharmaceutical composition as recited in claim 1 further comprising an intermediate enteric coating surrounding the core. 5. A pharmaceutical composition as recited in claim 1 wherein the NSAID comprises diclofenac from about 25 to 75 mg and the mantle coating comprises a prostaglandin formulation containing an amount of about 200 mcg of misoprostol. 6. A method of treating inflammation comprising orally administering to a patient in need of such treatment, a therapeutically effective amount to treat inflammation of a composition comprising a. a core consisting of a therapeutically-effective amount of a nonsteroidal anti-inflammatory agent selected from diclofenac and piroxicam; and b. a mantle coating surrounding the core comprising a therapeutically-effective amount of misoprostol. 7. A method as recited in claim 6 wherein the nonsteroidal anti-inflammatory agent comprises diclofenac. 8. A method as recited in claim 6 wherein the nonsteroidal anti-inflammatory agent comprises piroxicam. 9. A method as recited in claim 6 wherein the NSAID comprises diclofenac from about 25 to 75 mg and the mantle coating comprises a prostaglandin formulation containing an amount of about 200 mcg of misoprostol. 10. A pharmaceutical tablet composition comprising: a. a core comprising from about 25 to 75 mg of diclofenac sodium; b. an enteric coating surrounding the core; and c. a mantle coating surrounding the enteric coating, the mantle coating comprising from about 100 to about 200 .mu.g misoprostol. |
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