Claims for Patent: 5,629,021

Summary for Patent: 5,629,021

Title:	Micellar nanoparticles
Abstract:	The present invention relates to micellar nanoparticles and methods of their production. Micellar nanoparticles are made by hydrating a mixture of an oil, a stabilizer/surfactant, and an alcoholic initiator with an aqueous solution. These micellar nanoparticles are normally less than 100 nanometers in diameter. The micellar nanoparticles are particularly advantageous in delivering materials such as estradiol topically through the skin because their small size allows easy penetration.
Inventor(s):	Wright; D. Craig (Gaithersburg, MD)
Assignee:	Novavax, Inc. (Rockville, MD)
Application Number:	08/380,942
Patent Claims:	1. A micellar nanoparticle having a diameter of between about 25 and 1000 nm, said micellar nanoparticle comprising a lipophilic phase which includes an oil, a stabilizer and an alcohol-based initiator, hydrated with a suitable aqueous solution wherein said stabilizer is selected from the group consisting of Tween 60, Tween 80, nonylphenol polyethylene glycol ethers, and mixtures thereof. 2. The micellar nanoparticle of claim 1 wherein said initiator is selected from the group consisting of alcoholic materials containing methanol, ethanol and mixtures thereof. 3. The micellar nanoparticle of claim 2 wherein said initiator is selected from the group consisting of alcoholic materials containing 50% or higher ethanol, methanol, and mixtures thereof. 4. The micellar nanoparticle of claim 1 wherein said oil is selected from the group consisting vegetable oils, nut oils, fish oils, lard oil, mineral oils, squalane, tricaprylin, and mixtures thereof. 5. The micellar nanoparticle of claim 1 wherein said aqueous solution comprises a physiologically compatible solution. 6. The micellar nanoparticle of claim 1 wherein said aqueous solution is selected from the group consisting of water, and phosphate buffered saline. 7. The micellar nanoparticle of claim 1 wherein said aqueous phase has an active material dissolved or suspended therein. 8. The micellar nanoparticle of claim 1 wherein said oil has an active material dissolved or suspended therein. 9. The micellar nanoparticle of claim 1 wherein said initiator has an active material dissolved or suspended therein. 10. The micellar nanoparticle of claim 9 wherein said active material comprises estradiol. 11. The micellar nanoparticle of claim 1 wherein said micellar nanoparticle is dispersible in aqueous solution. 12. The micellar nanoparticle of claim 1 wherein the diameter of said micellar nanoparticle allows passage through a 0.2 mm filter.