Claims for Patent: 5,674,872

Summary for Patent: 5,674,872

Title:	Treatment of ovarian cancer
Abstract:	A method of treating ovarian cancer in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the water soluble camptothecin analog class.
Inventor(s):	Johnson; Randall Keith (Ardmore, PA)
Assignee:	SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:	08/411,056
Patent Claims:	1. A method of treating ovarian cancer in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the formula: ##STR3## wherein: a) X is hydroxy and R is trimethylammoniummethyl; b) X is hydroxy and R is N-methylpiperazinylmethyl; c) X is hydroxy and R is N-methylanilinomethyl; d) X is hydroxy and R is cyclohexylaminomethyl; e) X is hydroxy and R is N,N-dimethylaminoethyloxymethyl; f) X is hydroxy and R is cyclopropylaminomethyl; g) X is hydroxy and R is morpholinomethyl; h) X is hydroxy and R is aminomethyl; i) X is hydroxy and R is cyanomethyl; or j) X is hydroxy and R is dimethylaminomethyl or any pharmaceutically acceptable salts, hydrates and solyates thereof; wherein the course of therapy employed is from about 1.0 to about 2.5 mg/m.sup.2 of body surface area per day for about five consecutive days. 2. The method of claim 1 wherein the administration is oral. 3. The method of claim 1 wherein the administration is parenteral. 4. The method of claim 3 wherein the course of therapy employed is from about 1.5 to about 2 mg/m.sup.2 of body surface area per day for about five consecutive days. 5. The method of claim 4 wherein the course of therapy is repeated at least once at about a seven day to about a twenty-eight day interval. 6. The method of claim 3 wherein the administration is via short or long intravenous infusion. 7. The method of claim 6 wherein the administration is via a 30 minute intravenous infusion. 8. The method of claim 6 wherein the administration is via a 24 hour intravenous infusion. 9. The method of claim 6 wherein the compound is topotecan. 10. The method of claim 1 wherein the compound is topotecan.