Claims for Patent: 5,679,376

Summary for Patent: 5,679,376

Title:	Simethicone containing pharmaceutical compositions
Abstract:	A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.
Inventor(s):	Stevens; Charles A. (Lansdale, PA), Hoy; Michael R. (North Wales, PA), Roche; Edward J. (Paoli, PA)
Assignee:	McNeil-PPC, Inc. (Skillman, NJ)
Application Number:	08/455,443
Patent Claims:	1. A solid oral dosage form for the treatment of gastrointestinal distress comprising a therapeutically effective amount of a pharmaceutical for the treatment of gastric disorders selected from the group consisting of diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof, and combinations thereof; and a therapeutically effective amount of simethicone wherein the oral dosage form has a first portion containing the pharmaceutical and a second portion containing simethicone and the first and second portions are separated by a pharmaceutically acceptable polymeric barrier, which is impermeable to simethicone and the pharmaceutical. 2. The solid oral dosage form of claim 1 wherein the pharmaceutical comprises loperamide HCl. 3. The solid oral dosage form of claim 1 wherein the pharmaceutical comprises diphenoxylate. 4. The solid oral dosage form of claim 1 wherein the pharmaceutical comprises loperamide-N-oxide. 5. The solid oral dosage from of claim 1 wherein the barrier comprises a pharmaceutically acceptable film forming polymer.