Claims for Patent: 5,753,706

Summary for Patent: 5,753,706

Title:	Methods for treating renal failure
Abstract:	Methods of controlling phosphate metabolism and metabolic acidosis in patients suffering from renal failure and associated hyperphosphatemia or patients predisposed to development of a hyperphosphatemic condition are provided. The method in accordance with this invention comprises administering to a patient a ferric-containing compound selected from the group consisting of ferric citrate, ferric acetate, and combinations thereof. Therapeutic benefit can be realized in accordance with such method by administering the compound orally to a patient to contact and bind with ingested phosphate in the patient's digestive tract, and thereby prevent its intestinal absorption.
Inventor(s):	Hsu; Chen Hsing (Ann Harbor, MI)
Assignee:
Application Number:	08/794,328
Patent Claims:	1. A method of controlling phosphate retention in a patient suffering from hyperphosphatemia or a patient predisposed to development of a hyperphosphatemic condition, comprising the step of administering to the patient a therapeutically-effective amount of a compound selected from the group consisting of ferric citrate, ferric acetate and combinations thereof. 2. The method of claim 1, wherein the compound is administered to the patient orally. 3. The method of claim 1, wherein the compound is ferric citrate. 4. The method of claim 1, wherein the compound is ferric acetate. 5. The method of claim 1, wherein the therapeutically-effective amount of the compound is a unit dosage of about 500 mg to about 1000 mg. 6. A therapeutic composition in oral dosage form for controlling phosphate retention in patients having need for reduced absorption of dietary phosphate, said composition comprising on a per dose basis from about 500 mg to about 1000 mg of a compound selected from the group consisting of ferric citrate, ferric acetate and combinations thereof, and a pharmaceutically acceptable excipient for said oral dosage form. 7. The composition of claim 6, wherein the compound is ferric citrate. 8. The composition of claim 6, wherein the compound is ferric acetate. 9. A method of controlling serum phosphate metabolism and metabolic acidosis in a patient suffering from renal failure, comprising the step of administering to the patient a therapeutically-effective amount of a compound selected from the group consisting of ferric citrate, ferric acetate and combinations thereof. 10. The method of claim 9, wherein the compound is administered to the patient orally. 11. The method of claim 9, wherein the therapeutically-effective amount of the compound is a unit dosage of about 500 mg to about 1000 mg. 12. The method of claim 9, wherein the compound is ferric citrate. 13. The method of claim 9, wherein the compound is ferric acetate.