You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 23, 2024

Claims for Patent: 5,759,565

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 5,759,565

Title:	Galenic compositions comprising calcitonin and their use
Abstract:	Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nasal mucosa. The compositions are suitably adapted for administration in the form of a nasal spray.
Inventor(s):	Azria; Moise (Basel, CH), Cavanak; Thomas (Biel-Benken, CH)
Assignee:	Novartis Corporation (Summit, NJ)
Application Number:	07/815,457
Patent Claims:	1. A liquid pharmaceutical composition comprising 1) a pharmaceutically acceptable, aqueous liquid nasal carrier; 2) a therapeutically effective amount of a calcitonin or a pharmaceutically acceptable acid addition salt thereof, wherein said calcitonin is selected from the group consisting of salmon calcitonin, human calcitonin, porcine calcitonin and 1,7-Asu-eel calcitonin; and 3) about 0.002% to about 0.02% on a weight per volume basis of a benzalkonium chloride, said composition being in a form suitable for nasal administration. 2. A composition according to claim 1 for administration in the form of a spray and having a viscosity of less than 2.times.10.sup.-3 Pa.S. 3. A composition according to claim 1 wherein said composition is in the form of a nasal spray. 4. A composition according to claim 1 wherein said carrier comprises aqueous saline. 5. A composition according to claim 1 wherein said calcitonin, or salt is present in an amount of from about 100 to about 8,000 MRC units/ml. 6. A composition according to claim 1 wherein said calcitonin, or salt is present in an amount of from about 500 to about 4,000 MRC units/ml. 7. A composition according to claim 1 -wherein said calcitonin, or salt is present in an amount of from about 500 to about 2,500 MRC units/ml. 8. A composition according to claim 1 wherein said calcitonin, or salt is present in an amount of from about 1,000 to about 2,000 MRC units/ml. 9. A composition according to claim 1 wherein said calcitonin is salmon calcitonin. 10. A composition according to claim 1 comprising a non-ionic surfactant. 11. A composition according to claim 1 comprising a polyoxyethylene or polyoxypropylene ether. 12. A composition according to claim 1 comprising a polyoxyalkylene lauryl, cetyl, lanosteryl, dihydrocholesteryl or cholesteryl ether. 13. A composition according to claim 1 comprising a polyoxyethylene lauryl, cetyl or cholesteryl ether. 14. A composition according to claim 13 comprising a polyoxyethylene cholesteryl ether in which the number of repeating units in the polyoxyethylene moiety is from 16 to 26. 15. A composition according to claim 10 wherein said surfactant is present in an amount of from about 2.0 to about 200 mg/ml. 16. A composition according to claim 10 wherein said surfactant is present in an amount of from about 5 to about 15 mg/ml. 17. A composition according to claim 1 having a pH of from about 3 to about 5. 18. A composition according to claim 17 having a pH of from about 3.5 to 4.5. 19. A composition according to claim 17 comprising hydrochloric acid as the means to obtain the desired pH. 20. A composition according to claim 1 having an osmotic pressure of from about 260 to 380 mOsm/liter.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.