Claims for Patent: 5,795,864
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Summary for Patent: 5,795,864
| Title: | Stable omega conopetide formulations |
| Abstract: | Disclosed are formulations effective to stabilize omega conotoxin peptide preparations at elevated temperatures. Novel omega conopeptides also form part of the invention. |
| Inventor(s): | Amstutz; Gary Arthur (San Jose, CA), Bowersox; Stephen Scott (Menlo Park, CA), Gohil; Kishorchandra (Richmond, CA), Adriaenssens; Peter Isadore (Mountain View, CA), Kristipati; Ramasharma (Fremont, CA) |
| Assignee: | Neurex Corporation (Menlo Park, CA) |
| Application Number: | 08/496,847 |
| Patent Claims: |
1. A stable omega conopeptide formulation comprising an omega conopeptide and an anti-oxidant composition capable of preventing methionine oxidation.
2. The formulation of claim 1, wherein the anti-oxidant composition includes a carboxylic acid buffer. 3. The formulation of claim 2, wherein the carboxylic acid buffer is lactate buffer. 4. The formulation of claim 1, wherein the anti-oxidant is methionine. 5. The formulation of claim 1, wherein the anti-oxidant composition includes lactate buffer and methionine. 6. An omega-conopeptide SNX-273 having the sequence: SEQ ID NO: 35. 7. An omega conopeptide SNX-279 having the sequence SEQ ID NO: 36. |
