Claims for Patent: 5,814,639
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Summary for Patent: 5,814,639
| Title: | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
| Abstract: | The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds. |
| Inventor(s): | Liotta; Dennis C. (Stone Mountain, GA), Schinazi; Raymond F. (Decatur, GA), Choi; Woo-Baeg (North Brunswick, NJ) |
| Assignee: | Emory University (Atlanta, GA) |
| Application Number: | 08/017,820 |
| Patent Claims: |
1. .beta.-2'-Deoxy-5-fluoro-3'-thiacytidine.
2. A pharmaceutical composition comprising an effective HIV treatment amount for humans of .beta.-2'-deoxy-5-fluoro-3'-thiacytidine in a pharmaceutically acceptable carrier or diluent. |
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ISSN: 2162-2639
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