Claims for Patent: 5,843,901
✉ Email this page to a colleague
Summary for Patent: 5,843,901
| Title: | LHRH antagonist peptides |
| Abstract: | Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. |
| Inventor(s): | Roeske; Roger W. (Indianapolis, IN) |
| Assignee: | Advanced Research & Technology Institute (Bloomington, IN) |
| Application Number: | 08/480,494 |
| Patent Claims: |
1. A peptide compound comprising a structure:
wherein A is pyro-Glu, Ac-D-Nal, Ac-D-Qal, Ac-Sar, or Ac-D-Pal; B is His or 4-Cl-D-Phe; C is Trp, D-Pal, D-Nal, L-Nal-D-Pal(N-O), or D-Trp; D is Ser; E is N-Me-Ala, Tyr, N-Me-Tyr, Ser, Lys(iPr), 4-Cl-Phe, His, Asn, Met, Ala, Arg or Ile; F is D-Asn or D-Gln; G is Leu or Trp; H is Lys(iPr), Gln, Met, or Arg; I is Pro; and J is Gly-NH.sub.2 or D-Ala-NH.sub.2 ; or a pharmaceutically acceptable salt thereof. 2. A peptide compound comprising a structure: wherein A is pyro-Glu, Ac-D-Nal, Ac-D-Qal, Ac-Sar, or Ac-D-Pal; B is His or 4-Cl-D-Phe; C is Trp, D-Pal, D-Nal, L-Nal-D-Pal(N-O), or D-Trp; D is Ser; E is N-Me-Ala, Tyr, N-Me-Tyr, Ser, Lys(iPr), 4-Cl-Phe, His, Asn, Met, Ala, Arg or Ile; F is D-Asn; G is Leu or Trp; H is Lys(iPr), Gln, Met, or Arg; I is Pro; and J is Gly-NH.sub.2 or D-Ala-NH.sub.2 ; or a pharmaceutically acceptable salt thereof. 3. A peptide compound comprising a structure: Ac-D-Nal-4-Cl-D-Phe-D-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(iPr)-Pro-D-Ala-NH.sub. 2 ; or a pharmaceutically acceptable salt thereof. 4. A peptide compound comprising a structure: Ac-D-Nal-4-Cl-D-Phe-D-Pal-Ser-Tyr-D-Asn-Leu-Lys(iPr)-Pro-D-Ala-NH.sub.2 ; or a pharmaceutically acceptable salt thereof. 5. A pharmaceutical composition comprising the peptide compound of any one of claims 1, 2, 3 or 4, and a pharmaceutically acceptable carrier. |
