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Last Updated: December 22, 2024

Claims for Patent: 5,859,037

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Summary for Patent: 5,859,037

Title:	Sulfonylurea-glitazone combinations for diabetes
Abstract:	Combinations of a sulfonylurea antidiabetic agent and a glitazone antidiabetic agent are useful for treating diabetes mellitus and improving glycemic control.
Inventor(s):	Whitcomb; Randall Wayne (Ann Arbor, MI)
Assignee:	Warner-Lambert Company (Morris Plains, NJ)
Application Number:	08/970,057
Patent Claims:	1. A composition comprising from about 3 mg to about 250 mg of a sulfonylurea antidiabetic agent and from about 100 mg to about 1000 mg of a glitazone antidiabetic agent, said amounts of sulfonylurea and glitazone being synergistic for the treatment of non-insulin dependent diabetes mellitus in humans. 2. A composition of claim 1 wherein the sulfonylurea is selected from glisoxepid, glyburide, acetohexamide, chlorpropamide, glibornuride, tolbutamide, tolazamide, glipizide, gliclazide, gliquidone, glyhexamide, phenbutamide, and tolcyclamide. 3. A composition of claim 2 wherein the glitazone is selected from troglitazone, ciglitazone, pioglitazone, englitazone, TA 174, and BRL 49653. 4. A composition of claim 3 comprising troglitazone and glyburide. 5. A method of treating non-insulin dependent diabetes mellitus in humans comprising administering to a patient in need of treatment from about 3 mg to about 250 mg of a sulfonylurea antidiabetic agent in combination with about 100 mg to about 1000 mg of a glitazone antidiabetic agent, wherein said amounts are synergistic in the treatment of non-insulin dependent diabetes mellitus. 6. A method according to claim 5 wherein the sulfonylurea antidiabetic agent is selected from glisoxepid, glyburide, acetohexamide, chlorpropamide, glibornuride, tolbutamide, tolazamide, glipizide, gliclozide, gliquidone, glyhexamide, phenbentamide, and tolcyclamide. 7. A method according to claim 6 wherein the glitazone antidiabetic agent is selected from troglitazone, ciglitazone, pioglitazone, englitazone, TA 174, and BRL 49653. 8. A method according to claim 7 comprising a combination of glyburide and troglitazone.

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